If you choose to use feverfew, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. Do not use more of this product than is recommended on the label. Do not use different forms tablets, liquid, tincture, teas, etc of feverfew at the same time without medical advice.
Using different formulations together increases the risk of an overdose. The use of raw feverfew is possibly unsafe. Chewing fresh leaves can cause mouth sores, swelling of your lips or tongue, and loss of taste. Do not take topical for the skin feverfew by mouth. Topical forms of this product are for use only on the skin. Call your doctor if the condition you are treating with feverfew does not improve, or if it gets worse while using this product.
Feverfew can affect blood-clotting and may increase your risk of bleeding. If you need surgery, dental work, or a medical procedure, stop taking feverfew at least 2 weeks ahead of time. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra feverfew to make up the missed dose. This includes angelica dong quai , capsicum, clove, danshen, garlic, ginger, ginkgo, horse chestnut, panax ginseng, poplar, red clover, turmeric, and willow.
Get emergency medical help if you have any of these signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Although not all side effects are known, feverfew is thought to be likely safe when taken for a short period of time up to 4 months. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Do not take feverfew without medical advice if you are using a medication to treat any of the following conditions:. This list is not complete. Other drugs may interact with feverfew, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this product guide. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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Measure content performance. Develop and improve products. List of Partners vendors. Feverfew Tanacetum parthenium is a plant belonging to the sunflower family. Also known as "featherfew" and "wild chamomile," It has long been used as an herbal remedy in European folk medicine. Feverfew contains a compound called parthenolide, which may help to ease muscle spasms, reduce inflammation, and prevent the constriction of blood vessels in the brain.
Feverfew leaves either dried or fresh and fever extracts are purported to have many potential benefits. Not all of these effects are supported by scientific evidence. In alternative medicine, feverfew is typically used as a herbal remedy for the following conditions:. There is not enough evidence to support the use of feverfew for these conditions. Although research on feverfew's effects is limited, studies have at potential feverfew benefits to treat these conditions:.
In a study of migraine patients, researchers found that those who took feverfew extract for 16 weeks experienced 1. Study members who took a placebo for the same amount of time experienced 1.
In a review of five clinical trials, however, investigators found insufficient evidence to suggest that feverfew is more effective than placebo in preventing migraine. Test-tube experiments have demonstrated that feverfew may help fight the inflammation associated with rheumatoid arthritis , although no human studies have proven feverfew to be more useful than placebo in the treatment of this disease.
In a study, scientists discovered that parthenolide extracted from feverfew inhibited the growth of pancreatic cancer cells in the lab. While medical experts report that that feverfew seems to be well tolerated among cancer patients, it's too soon to tell whether feverfew may be useful in the treatment of pancreatic cancer.
Feverfew is likely safe when taken for a short period of time in appropriate doses. However, certain side effects may occur.
These side effects may include minor stomach upset such as nausea, diarrhea, and flatulence , red itchy rash, and mouth ulcerations from chewing fresh feverfew leaves. Patients who stop long-term use of feverfew may also experience muscle stiffness, moderate pain, and anxiety.
If you're allergic to ragweed, chrysanthemum, or marigold, you may be sensitive to feverfew. Anyone taking anticoagulant or antiplatelet medication should consult their doctor before using feverfew.
Parthenolide content is calculated in milligrams. Parthenolide is detectable at the sub-nanogram level and calculated in micrograms recovered at 1 or 2hours, as shown in Table 2. Even the samples tested to contain the highest concentration of parthenolide still contained less than the amount stated on the product labels by an order of magnitude. Several factors may explain these results. Average Amount of Parthenolide Recovered at pH 3 m g. Average Amount of Parthenolide Recovered at pH 7 m g.
Table 2 Average amount of parthenolide recovered, pH3 and pH7 Figure 1 Average percent parthenolide recovery, overall. Figure 2 Average percent parthenolide recovery. A 1 hour; B 2 hours Conclusion Parthenolide in commercial feverfew capsules may be poorly bioavailable due to low aqueous solubility and the inability to withstand the extreme pH of the stomach. Although products may contain higher concentrations of parthenolide than detected in this dissolution study, according to label claim, consumers are advised to purchase only those products which bear the symbol of a reliable independent testing laboratory.
To avoid lengthy residence time in the harsh environment of the stomach, it may also be advisable to take encapsulated powdered feverfew products on an empty stomach with plenty of water. As a final, noteworthy point of discussion, all of the products tested in this study were analyzed prior to their date of expiration, and were manufactured prior to the release of cGMP guidelines under US federal law in July, This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.
Withdrawal Guidlines. Publication Ethics. Withdrawal Policies Publication Ethics. Research Article Volume 2 Issue 4. It is known that parthenolide is poorly water-soluble. This can impact the amount able to dissolve at any pH.
The use of biorelevant dissolution media would present opportunities to improve extraction efficiency from products during dissolution testing. A fraction of parthenolide could be lost during manipulation in the step of ethyl acetate extraction prior to hplc analysis. In addition to the low levels of parthenolide observed in all samples, the recoverable concentration varied by product, duration of time in the dissolution apparatus and the pH of dissolution media, as shown in Figure 2.
This can be explained by several factors: Parthenolide originally contained in in products at the time of manufacture may decompose over time and under various environmental conditions during storage, distribution and display on the shelf at commercial retail outlets.
Spurious compounds from the complex mixture of plant constituents in the extract may affect retention volume and the ability to integrate AUC accurately.
Environmental conditions in the laboratory fluctuate during the course of the day, possibly affecting retention volume and absorbance measurements. Experimental error in the preparation of the daily standard curve may account for unexpectedly low concentrations of parthenolide in some samples. Figure 1 Average percent parthenolide recovery, overall. A 1 hour; B 2 hours. Parthenolide in commercial feverfew capsules may be poorly bioavailable due to low aqueous solubility and the inability to withstand the extreme pH of the stomach.
A review of 12 commonly used medicinal herbs.
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