Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. In good general health with absence of significant health problems as determined by medical history, physical examination, and laboratory screening performed during screening visits. Subject will reside within a 60 mile or less radius from Bethesda, MD during the period of participation in the trial. Females subjects must be of non-childbearing potential i.
Willingness to attend all scheduled visits and able to comply with all trial procedures e. Confirmatory testing may be required based on the initial assay used and the result.
Subject is willing not to use antiviral therapy less than or equal to 2 days before and less than or equal to 3 days after each injection. Subject is willing to forgo receipt of a licensed, live vaccine in the 30 days preceding each dose of vaccine or in the 30 days following each dose of vaccine.
The inactivated flu vaccine can be used greater than or equal to 14 days before or greater than or equal to 14 days after administration of study vaccine, if this is felt to be necessary. Persons who have close contact with infants or immunocompromised individuals agree to avoid such contact for 3 days after each injection. Subject must be willing to allow storage of blood, swabs of skin or mucosa, biopsies of skin lesions, or, for female subjects, cervicovaginal secretions if collected for future research.
An individual fulfilling any of the following criteria is to be excluded from trial enrollment: Subject is pregnant or lactating OR planning to become pregnant timeframe that begins 30 days prior to the first vaccination and ends 30 days after the third vaccination.
Body Mass Index greater than Participation in another clinical trial investigating a vaccine, drug, medical device, or medical procedure in the 4 weeks preceding the first trial vaccination or or planned participation during the study period up to 6 months after the last dose of vaccine or placebo.
The non-interventional follow-up for an earlier study e. Severe active infection or serious HSV-2 related or unrelated medical conditions that, in the opinion of the investigator, would prevent study completion. Subjects with 6 or more symptomatic recurrences of genital herpes disease within the year prior to Day 0. A history of HSV infection of the eye e. A history of herpes gladiatorum, herpetic whitlow or eczema herpeticum.
A history of lesions caused by HSV on either arm. A history of herpes-associated erythema multiforme. A history of a clinically significant autoimmune disorder. Known or suspected congenital or acquired immunodeficiency Receipt of anti-cancer chemotherapy or radiation therapy within the preceding 6 months. Subjects using corticosteroids excluding topical, inhaled or nasal or any immunomodulating drugs within 42 days prior to the first vaccination. An immunosuppressive dose of corticosteroids is defined as greater than or equal to 10 mg prednisone equivalent per day for greater than or equal to 14 days.
Subjects without a spleen. Subjects receiving immunoglobulin within the past 6 months or anticipated receipt of immunoglobulin during the 28 days following vaccination. Bleeding disorder, or receipt of anticoagulants that, in the opinion of the Investigator, would interfere with the subject s participation in the trial.
Prior vaccination against herpes simplex virus. Known allergy or intolerance to vaccine components [e. Deprived of freedom by an administrative or court order, or in an emergency setting, or hospitalized involuntarily. Current alcohol abuse or drug abuse or addiction. Chronic illness that, in the opinion of the Investigator, is at a stage where it might interfere with trial conduct or completion. Employee of the NIH or contractor working at the NIH, with direct involvement in the proposed study as well as family members i.
Any condition that the PI thinks might compromise the person s ability to comply with the requirements of the study. Justification for Exclusion of Women and Children: Exclusion of Women: Pregnancy: Pregnant women are excluded from this study because the effects of HSV on the developing human fetus are unknown with the potential for teratogenic or abortifacient effects. Breast-feeding: Because there is an unknown but potential risk for adverse events in nursing infants secondary to vaccination of the mother with HSV, breastfeeding should be discontinued if the mother will be vaccinated with HSV What does it mean when someone steps on a married couples picture and it cracks.
Asked by: Rodrigo. Ads by Google. This site is best viewed while logged in. Top Solutions. For a person it means: African American For a group: alcoholics anonymous. The game 4 pics Add your answer. Was this answer helpful? Yes No. Anonymous 0. Suggested Solutions 10 What's this? The game 4 pics 1 word main objective is to guess the word that has one thing in common.
For the first question, based from your description , the possible five letters for a wedding couple dancing, an old couple dancing, a cartoon couple dancing and a couple dancing is "DANCE. For the second questions, based from your clues, the seven letters that best described for a married couple , a couple in the kitchen, an old couple and a man wearing a suit and a heart shape box is "HUSBAND.
Was this comment helpful? This answer closely relates to:. You have given the clues: 1. He is the groom. He is the better half of a WIFE. If you take a look at the clues, the first clue shows an old couple. You will see that the husband is old. On the second clue, you will see a husband and wife and they were just married.
On the third clue, you will see a husband-to-be. There is a man proposing. And on the fourth clue, you will see the husband and wife, or the couple who are cooking.
I think all your clues have couples on it. So I guess this is the right word for this. Originally Posted by Moses. All times are GMT The time now is AM. User Name. Remember Me?
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Page 1 of 2. Next ». Thread Tools. Rate Thread. Quote: Not sure what "bf" means either. The gift that keeps on giving. Herpes Simplex Virus positive.
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